I find it does make a difference, as only4teeth has mentioned.
How I deal with it is like this:
If I have two notes exactly the same in UNC, except on has cutting cup, and one does not.
When trading/selling, they will be described as this: (nice and simple)
GEM UNC (with no cutting cup)
or UNC (b/c of cutting cup)
From the higher denom.s I have gone through, it is like 100:1 for cutting cups to notes without.