I have heard the term "foxing" being applied to some brown spots on notes. I found the following definition of "foxing" at Wikipedia.
Foxing (from Ferric OXide, or from the fox-like color of the stain) is the effect on certain papers of the oxidation of iron or other substances in the pulp or rag from which the paper was made. It is responsible for the spots and browning seen on old books, documents, postage stamps, and so forth.
While unsightly, and a negative factor in the value of the paper item for collectors, foxing does not affect the integrity of the paper.
My question is - is foxing a spontaneous event or did the note - at one point - get wet or something else happen to it for foxing to start?